ISBN: 978-0-6450017-8-5
Exon Publications, Brisbane, Australia

Andreas M. Grabrucker, PhD (Editor)
Department of Biological Sciences, University of Limerick, Limerick, Ireland


Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.


Published: 2021-08-20


Tobias M. Böckers

Page vii


Andreas M. Grabrucker, PhD

Pages ix-x

Autism Spectrum Disorders: Etiology and Pathology

Ann Katrin Sauer, MSC, Janelle Stanton, MSC, Sakshi Hans, MSC, Andreas Grabrucker, PHD

Pages 1-15

Autism Spectrum Disorders: Diagnosis and Treatment

Ronan Lordan, PHD, Cristiano Storni, PHD, Chiara Alessia De Benedictis, MSC

Pages 17-32

Autism, Adverse Events, and Trauma

Ella Lobregt-van Buuren, MSC, Marjolijn Hoekert, PHD, Bram Sizoo, PHD

Pages 33-42

Multisensory Processing in Autism Spectrum Disorders

Sayaka Kawakami, PHD, Sadao Otsuka, PHD

Pages 43-54

Atypical Sensory Characteristics in Autism Spectrum Disorders

Yoshiro Morimoto, MD, PHD, Akira Imamura, MD, PHD, Naoki Yamamoto, MD, Shinji Kanegae, MD, PHD, Hiroki Ozawa, MD, PHD, Ryoichiro Iwanaga, PHD

Pages 55-66

Genetic Overlap Among Autism Spectrum Disorders and Other Neuropsychiatric Disorders

Yoshiro Morimoto, MD, PHD, Naoki Yamamoto, MD, Shinji Kanegae, MD, PHD, Ryosuke Matsuzaka, MD, PHD, Hiroki Ozawa, MD, PHD, Akira Imamura, MD, PHD

Pages 67-78

The Gut-Microbiota-Brain Axis in Autism Spectrum Disorder

Giselle C. Wong, MSC, Johanna M. Montgomery, PHD, Michael W. Taylor, PHD

Pages 95-113


Pages 115-117